The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Feb. 13, 2013
Applicant:
University of Tsukuba, Ibaraki, JP;
Inventors:
Assignee:
UNIVERSITY OF TSUKUBA, Ibaraki, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/46 (2006.01); A61K 47/48 (2006.01); C07D 233/91 (2006.01); C07D 403/06 (2006.01); C07H 15/252 (2006.01); C07D 475/08 (2006.01); C07H 15/244 (2006.01); C07H 19/06 (2006.01); A61K 31/196 (2006.01); A61K 31/198 (2006.01); A61K 31/519 (2006.01); A61K 31/58 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); C07H 15/24 (2006.01); C07D 487/04 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48061 (2013.01); A61K 31/196 (2013.01); A61K 31/198 (2013.01); A61K 31/519 (2013.01); A61K 31/58 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01); C07D 233/91 (2013.01); C07D 403/06 (2013.01); C07D 475/08 (2013.01); C07D 487/04 (2013.01); C07H 15/24 (2013.01); C07H 15/244 (2013.01); C07H 15/252 (2013.01); C07H 19/06 (2013.01); C07J 43/003 (2013.01);
Abstract
Provided is a prodrug of 2-nitro-1-imidazolepropionic acid and a therapeutically active organic compound having on the molecule an amino group, a cyclic amino group or a hydroxyl group, particularly a prodrug in which the therapeutically active organic compound is selected from among antitumor agents. The prodrug cleaves specifically under hypoxic conditions in vivo to exhibit the inherent therapeutic activity.