The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Oct. 16, 2014
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Silvia Muro Galindo, Silver Spring, MD (US);
Vladimir R. Muzykantov, Bryn Athyn, PA (US);
Edward Howard Schuchman, Haworth, NJ (US);
Icahn School of Medicine at Mount Sinai, New York, NY (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal proteins to cell surface proteins that allow their internalization via non-clathrin pathways. The present invention further relates to the use of the compositions and methods for enzyme replacement therapy of lysosomal storage diseases. Nucleic acids, recombinant cells and kits useful for making and using the compositions of the invention are also provided.