The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 2017
Filed:
Nov. 17, 2015
Applicant:
Nucana Biomed Limited, Camberley, GB;
Inventors:
Christopher McGuigan, Cardiff, GB;
Jan Balzarini, Heverlee, BE;
Magdalena Slusarczyk, Cardiff, GB;
Blanka Gonczy, Cardiff, GB;
Paola Murziani, Cardiff, GB;
Assignee:
NuCana BioMed Limited, , GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7072 (2006.01); A61K 45/06 (2006.01); C07F 9/655 (2006.01); C07F 9/6558 (2006.01); C07F 9/6584 (2006.01); C07H 19/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7072 (2013.01); A61K 45/06 (2013.01); C07F 9/65515 (2013.01); C07F 9/65586 (2013.01); C07F 9/65844 (2013.01); C07H 19/10 (2013.01);
Abstract
Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with-infected cells and/or with cells with a raised level of thymidylate synthase.