The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2017
Filed:
Dec. 30, 2014
Korea Research Institute of Chemical Technology, Daejeon, KR;
The Catholic University of Korea Industry-academic Cooperation Foundation, Seoul, KR;
Heeyeong Cho, Daejeon, KR;
Hee-Jong Lim, Daejeon, KR;
Ge Hyeong Lee, Daejeon, KR;
Woo Kyu Park, Chungcheongbuk-do, KR;
Hyeon Young Kim, Daejeon, KR;
Dae Young Jeong, Daejeon, KR;
Wan Uk Kim, Seoul, KR;
Chul Soo Cho, Seoul, KR;
Su Jung Park, Gyeonggi-do, KR;
Eun Jin Han, Gyeongsangnam-do, KR;
Abstract
The preset invention relates to a novel 8-oxoprotoberberine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5 containing the same as an active ingredient. The novel 8-oxoproteoberberine derivative or the pharmaceutically acceptable salt thereof according to the present invention can be useful in a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5, particularly rheumatoid arthritis or inflammatory diseases, since it is ascertained that the derivative or a pharmaceutically acceptable salt thereof has remarkably increased oral absorption compared with known protoberberine due to an improvement in the properties thereof, and inhibits the activity of NFAT5 and the secretion of inflammatory cytokines and reduces the expression of NAFT5 in mice with rheumatoid arthritis by directly inhibiting the transcription of NFT5.