The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2017

Filed:

Feb. 17, 2016
Applicant:

Albany Molecular Research, Inc., Albany, NY (US);

Inventors:

Peter Guzzo, Niskayuna, NY (US);

Matthew David Surman, Albany, NY (US);

Alan John Henderson, Albany, NY (US);

May Xiaowu Jiang, Guilderland, NY (US);

Mark Hadden, Albany, NY (US);

James Grabowski, Castleton on Hudson, NY (US);

Alexander Usyatinsky, Troy, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 521/00 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 519/00 (2013.01); C07D 521/00 (2013.01);
Abstract

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein Ris H or optionally substituted alkyl; R, R, Rare each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF, and —CN; G is —CRR—NR— or —NR—CRR; Ris H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R, —C(═O)—O—R, or —C(═O)—NRR; Rand Rare each optionally substituted alkyl or optionally substituted heterocycle; R, R, R, R, R, R, Rand Rare each independently selected from H or optionally substituted alkyl; Rand Rare each independently H or halogen; L is —CH—O—, —CHCH—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.


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