The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2017

Filed:

Oct. 10, 2012
Applicant:

Astrazeneca Ab, Södertälje, SE;

Inventors:

Anna Minidis, Södertälje, SE;

Fredrik Rahm, Macclesfield, GB;

Jenny Viklund, Macclesfield, GB;

Assignee:

ASTRAZENECA AB, Södertälje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/40 (2006.01); A61K 31/44 (2006.01); C07D 209/96 (2006.01); C07D 209/54 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 491/107 (2006.01); C07D 207/34 (2006.01); A61K 31/403 (2006.01); A61K 31/407 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01);
U.S. Cl.
CPC ...
C07D 209/54 (2013.01); A61K 31/403 (2013.01); A61K 31/407 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 207/34 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 491/107 (2013.01);
Abstract

Beta-secretase inhibitors, of formula (I) as described in the specification, pharmaceutical compositions comprising them and therapeutic methods using them for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ('mild cognitive impairment'), Alzheimer's Disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.


Find Patent Forward Citations

Loading…