The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 16, 2017

Filed:

Aug. 18, 2015
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Peter Crooks, Nicholasville, KY (US);

Linda Dwoskin, Lexington, KY (US);

Guangrong Zheng, Lexington, KY (US);

Sangeetha Sumithran, Lexington, KY (US);

David Allen, Rootstown, OH (US);

Zhenfa Zhang, Lexington, KY (US);

Paul Lockman, Amarillo, TX (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/439 (2006.01); A61K 31/395 (2006.01); C07D 471/16 (2006.01); C07D 471/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/439 (2013.01); A61K 31/395 (2013.01); C07D 471/06 (2013.01); C07D 471/16 (2013.01);
Abstract

Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.


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