The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 09, 2017

Filed:

Apr. 16, 2014
Applicant:

University of Washington Through Its Center for Commercialization, Seattle, WA (US);

Inventors:

Thomas Matula, Kirkland, WA (US);

Andrew A. Brayman, Edmonds, WA (US);

Oleg A. Sapozhnikov, Seattle, WA (US);

Brian MacConaghy, Kent, WA (US);

Jarred Egan Swalwell, Shoreline, WA (US);

Camilo Perez, Seattle, WA (US);

Assignee:

University of Washington, Seattle, WA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); G01N 21/53 (2006.01); G01N 21/64 (2006.01); G01N 1/40 (2006.01); B01L 3/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 21/53 (2013.01); B01L 3/502761 (2013.01); B01L 3/502784 (2013.01); G01N 1/4077 (2013.01); G01N 21/6486 (2013.01); B01L 3/502723 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/0436 (2013.01); G01N 2001/4066 (2013.01); G01N 2015/1081 (2013.01); G01N 2021/6439 (2013.01);
Abstract

Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.


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