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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9644221 B1

PDFFull Text
Date of Patent:
May. 09, 2017

Filed:

Mar. 27, 2013

Method of producing chemical by continuous fermentation and continuous fermentation apparatus

Applicant:

Toray Industries, Inc., Tokyo, JP;

Inventors:

Satoko Kanamori, Otsu, JP;

Hideki Sawai, Tokai, JP;

Norihiro Takeuchi, Otsu, JP;

Assignee:

Toray Industries, Inc., , JP;

Attorney:

DLA Piper LLP (US)

Primary Examiner:

Ruth Davis

Int. Cl.
CPC ...
C12P 1/00 (2006.01); C12P 13/24 (2006.01); C12P 7/56 (2006.01); C12P 13/04 (2006.01); C12M 1/00 (2006.01); C12M 1/26 (2006.01); C12M 1/34 (2006.01); C12P 13/00 (2006.01); C12P 13/06 (2006.01); C12P 13/08 (2006.01); C12P 13/10 (2006.01); C12P 13/12 (2006.01); C12P 13/14 (2006.01); C12P 13/20 (2006.01); C12P 13/22 (2006.01);
U.S. Cl.
CPC ...
C12P 13/24 (2013.01); C12M 29/04 (2013.01); C12M 33/14 (2013.01); C12M 41/34 (2013.01); C12P 7/56 (2013.01); C12P 13/001 (2013.01); C12P 13/04 (2013.01); C12P 13/06 (2013.01); C12P 13/08 (2013.01); C12P 13/10 (2013.01); C12P 13/12 (2013.01); C12P 13/14 (2013.01); C12P 13/20 (2013.01); C12P 13/222 (2013.01); C12P 13/225 (2013.01); C12P 13/227 (2013.01);
Abstract

A method of producing a chemical includes culturing cells in a culture solution in a fermentor to ferment a feedstock to produce a chemical; supplying the culture solution containing the chemical produced in the culturing to a plurality of separation membrane units arranged in parallel; filtering the culture solution supplied in the supplying to separate a permeate containing the chemical; refluxing a retentate that is not filtered in the filtering to the fermentor; and supplying a gas containing oxygen to the plurality of separation membrane units while a supply amount is changed to at least two different values to perform scrubbing, wherein the supply amount and supply time of the gas containing oxygen supplied in the culturing and the supplying the gas are set so that a kLa value is within a predetermined range from an optimal kLa value for the cells cultured in the culturing.

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