The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Mar. 11, 2014
Applicant:
Advaxis, Inc., East Princeton, NJ (US);
Inventors:
Paulo Maciag, Northbrook, IL (US);
Anu Wallecha, Yardley, PA (US);
Vafa Shahabi, Valley Forge, PA (US);
Assignee:
ADVAXIS, INC., East Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12N 15/74 (2006.01); A61K 39/00 (2006.01); C07K 14/47 (2006.01); C07K 14/515 (2006.01); A61K 39/39 (2006.01);
U.S. Cl.
CPC ...
C12N 15/74 (2013.01); A61K 39/0011 (2013.01); A61K 39/39 (2013.01); C07K 14/4748 (2013.01); C07K 14/515 (2013.01); A61K 2039/523 (2013.01); A61K 2039/6006 (2013.01);
Abstract
Provided herein are recombinantstrains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into thegenome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.