The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Aug. 13, 2012
Applicant:
Richard Reinier Zwaal, Heverlee, BE;
Inventor:
Richard Reinier Zwaal, Heverlee, BE;
Assignee:
ThromboGenics NV, Heverlee, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/68 (2006.01); A61K 38/17 (2006.01); A61K 38/48 (2006.01); C12Q 1/37 (2006.01); C07K 14/47 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6435 (2013.01); A61K 38/1709 (2013.01); A61K 38/484 (2013.01); A61K 45/06 (2013.01); C07K 14/47 (2013.01); C12Q 1/37 (2013.01); C12Y 304/21007 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatalytic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.