The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 09, 2017

Filed:

Apr. 25, 2013
Applicants:

Riken, Wako-shi, Saitama, JP;

Akifumi Matsuyama, Wako-shi, Saitama, JP;

Inventors:

Akifumi Matsuyama, Saitama, JP;

Hanayuki Okura, Hyogo, JP;

Assignees:

RIKEN, Saitama, JP;

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61L 27/38 (2006.01); A61K 35/34 (2015.01); A61K 35/28 (2015.01); A61L 27/54 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 35/28 (2013.01); A61K 35/34 (2013.01); A61L 27/3834 (2013.01); A61L 27/3873 (2013.01); A61L 27/3895 (2013.01); A61L 27/54 (2013.01); A61L 2300/204 (2013.01); A61L 2430/20 (2013.01); A61L 2430/30 (2013.01); C12N 2500/46 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1384 (2013.01);
Abstract

The present invention relates to a method for producing a cell population comprising myocardium-committed cells that differentiate into and survive as myocardial cells under a myocardial tissue environment. Specifically, the method is characterized in that adipose-tissue-derived multi-lineage/multi-potent progenitor cells are cultured in the presence of a polyamine. The present invention further relates to a cell population comprising the myocardium-committed cells, a cell preparation comprising the cell population, or a cell sheet. The present invention further relates to a method for treating a heart disease, which comprises administering the cell population to a subject.


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