The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Sep. 25, 2013
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v., München, DE;
Heike Boehm, Weinheim, DE;
Valentin Hagel, Springe, DE;
Tabea Mundinger, Stuttgart, DE;
Isabell Nuss, Munich, DE;
Seraphine Valeska Wegner, Heidelberg, DE;
Sabine Laschat, Boeblingen, DE;
Markus Manfred Mateescu, Constance, DE;
Abstract
The present invention relates to novel cross-linkers for hydrogels, in particular for hyaluronan hydrogels, corresponding hydrogels including said cross-linkers and various applications thereof. The cross linker of the invention is a bi- or multifunctional cross-linker comprising or consisting of an aromatic or heteroaromatic ring system with 3-6 C atoms which is coupled via functional groups on at least 2 ring positions with at least 2 terminal groups capable to form a covalent bond with thiol or amino groups, in particular with thiol groups in a thiol-en reaction. The cross-linker may be charged or uncharged. In a specific embodiment, the terminal groups are coupled to carboxy groups of the aromatic or heteroaromatic ring system via an ester or amide bond. More specifically, the cross-linker of the invention is a derivative of pyridine-3,5-dicarboxylic acid or a corresponding pyridinium salt thereof wherein 2 terminal groups are coupled to the carboxy groups of the pyridine or pyridinium core via an ester or amide bond. In a preferred embodiment, the cross-linker if N,N-bis(2-acrylamidoethyl) pyridine-3,5-dicarboxamide or a 3,5-bis((2-acryl-amidoethyl) carbamoyl)-1-methylpyridin-1-ium-halogenide.