The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Jun. 22, 2010
Paul Habermann, Frankfurt am Main, DE;
Gerhard Seipke, Frankfurt am Main, DE;
Roland Kurrle, Frankfurt am Main, DE;
Gunter Muller, Frankfurt am Main, DE;
Mark Sommerfeld, Frankfurt am Main, DE;
Norbert Tennagels, Frankfurt am Main, DE;
Georg Tschank, Frankfurt am Main, DE;
Ulrich Werner, Frankfurt am Main, DE;
Paul Habermann, Frankfurt am Main, DE;
Gerhard Seipke, Frankfurt am Main, DE;
Roland Kurrle, Frankfurt am Main, DE;
Gunter Muller, Frankfurt am Main, DE;
Mark Sommerfeld, Frankfurt am Main, DE;
Norbert Tennagels, Frankfurt am Main, DE;
Georg Tschank, Frankfurt am Main, DE;
Ulrich Werner, Frankfurt am Main, DE;
Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, DE;
Abstract
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.