The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Jul. 25, 2014
Applicant:
Yale University, New Haven, CT (US);
Inventor:
Alanna Schepartz, Wilton, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); A61K 38/12 (2006.01); A61K 38/10 (2006.01); C07K 14/485 (2006.01); C07K 7/54 (2006.01); C07K 7/50 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); C07K 7/50 (2013.01); A61K 38/10 (2013.01);
Abstract
The present invention includes a novel class of allosteric modulators that target a protein having a juxtamembrane segment. In another embodiment, the allosteric modulator is a peptide mimetic that is capable of interacting with an α-helix or a coiled coil domain of a protein. In one embodiment, the peptide mimetic binds to at least an α-helix or a coiled coil domain of EGFR and modulates its activity.