The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Nov. 14, 2014
Emcure Pharmaceuticals Limited, Pune, IN;
Mukund K. Gurjar, Pune, IN;
Narendra K. Tripathy, Pune, IN;
Kaliaperumal Neelakandan, Pune, IN;
Prasad P. Panchabhai, Pune, IN;
Nandala Srinivas, Pune, IN;
Prabhakaran Balasubramanian, Pune, IN;
Sandip B. Buchude, Pune, IN;
Balaji R. Mugale, Pune, IN;
Pravin P. Ahirrao, Pune, IN;
Samit S. Mehta, Pune, IN;
EMCURE PHARMACEUTICALS LIMITED, Pune, IN;
Abstract
A process for preparation of diethyl 2-aetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (Ia) having associated impurities below the regulatory limits.