The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Mar. 14, 2014
Baxter International Inc., Deerfield, IL (US);
Baxter Healthcare SA, Glattpark (Opifkon), CH;
Northwestern University, Evanston, IL (US);
Ton That Hai, Round Lake, IL (US);
John-Bruce Devault Green, Buffalo Grove, IL (US);
Timothy Michael Fulghum, Lakemoor, IL (US);
Phillip Byron Messersmith, Clarendon Hills, IL (US);
Tadas Stanislovas Sileika, Northbrook, IL (US);
BAXTER INTERNATIONAL INC., Deerfield, IL (US);
BAXTER HEALTHCARE SA, Glattpark (Opfikon), CH;
NORTHWESTERN UNIVERSITY, Evanston, IL (US);
Abstract
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.