The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Feb. 27, 2014
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventor:
Jason E. Gestwicki, Moss Beach, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/395 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 38/05 (2006.01); C07D 277/64 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/395 (2013.01); A61K 31/428 (2013.01); A61K 38/05 (2013.01); C07D 277/64 (2013.01); C07D 417/14 (2013.01);
Abstract
Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.