The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Oct. 06, 2015
Applicant:
Sirna Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Mark Cameron, Brick, NJ (US);
Jennifer R. Davis, Richboro, PA (US);
Andrea R. Geiser, Lansdale, PA (US);
Matthew G. Stanton, Marlton, NJ (US);
Vladislav V. Telyatnikov, Willow Grove, PA (US);
Lu Tian, Jamison, PA (US);
Weimin Wang, Churchville, PA (US);
Assignee:
SIRNA THERAPEUTICS, INC., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1272 (2013.01); A61K 31/7088 (2013.01); C07J 41/0055 (2013.01); C07J 43/003 (2013.01);
Abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.