The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Jan. 10, 2011
Patrice Caillat, Grenoble, FR;
François Berger, Meylan, FR;
Raymond Campagnolo, Grenoble, FR;
Marie-line Cosnier, Grenoble, FR;
Affif Zaccaria, Le Pont de Claix, FR;
Patrice Caillat, Grenoble, FR;
François Berger, Meylan, FR;
Raymond Campagnolo, Grenoble, FR;
Marie-Line Cosnier, Grenoble, FR;
Affif Zaccaria, Le Pont de Claix, FR;
Commissariat a l'Energie Atomique et aux Energies Alternatives, Paris, FR;
Institut National de la Sante Et de la Recherche Medicale (INSERM), Paris, FR;
Centre Hospitalier Universitaire De Grenoble, Grenoble, FR;
Universite Jospeh Fourier, Grenoble, FR;
Abstract
The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device () according to the invention comprises: —a sampling tip () having a contacting end intended to be introduced into a medium containing said fluid, and—the or each capturing unit which is bound to said end and which comprises a capture substrate () defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer () designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.