The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 09, 2017

Filed:

Jun. 25, 2015
Applicants:

International Business Machines Corporation, Armonk, NY (US);

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Julian M. W. Chan, Ottawa, CA;

James L. Hedrick, Pleasanton, CA (US);

Robert J. Ono, San Jose, CA (US);

Jye Yng Teo, Singapore, SG;

Yi Yan Yang, Singapore, SG;

Mu San Zhang, San Jose, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/74 (2006.01); A01N 33/12 (2006.01); C08G 73/02 (2006.01);
U.S. Cl.
CPC ...
A01N 33/12 (2013.01); C08G 73/024 (2013.01); C08G 73/0206 (2013.01); C08G 73/0213 (2013.01);
Abstract

Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.


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