The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2017
Filed:
Jun. 25, 2013
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Richard T. Lee, Weston, MA (US);
Parth Patwari, Cambridge, MA (US);
Francesco Loffredo, Boston, MA (US);
James Pancoast, Cambridge, MA (US);
Zheng Xin Dong, Holliston, MA (US);
Todd Vannelli, Milford, MA (US);
The Brigham and Women's Hospital, Inc, Boston, MA (US);
Abstract
The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fusion proteins in methods to deliver IGF-1 to the cartilage for the treatment of a cartilage related disease and disorder in a subject.