The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2017
Filed:
Mar. 13, 2014
Konstantin Petrukhin, New Windsor, NY (US);
Christopher Cioffi, Albany, NY (US);
Graham Johnson, Sanbornton, NH (US);
Nicoleta Dobri, New York, NY (US);
Emily Freeman, Albany, NY (US);
Ping Chen, Albany, NY (US);
Michael Conlon, Albany, NY (US);
Lei Zhu, Albany, NY (US);
Konstantin Petrukhin, New Windsor, NY (US);
Christopher Cioffi, Albany, NY (US);
Graham Johnson, Sanbornton, NH (US);
Nicoleta Dobri, New York, NY (US);
Emily Freeman, Albany, NY (US);
Ping Chen, Albany, NY (US);
Michael Conlon, Albany, NY (US);
Lei Zhu, Albany, NY (US);
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Abstract
The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.