The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 02, 2017

Filed:

Jul. 15, 2016
Applicant:

Oakwood Laboratories Llc, Oakwood Village, OH (US);

Inventors:

Tracy Richey, Kent, OH (US);

Bagavathikanun Chithambara Thanoo, Brecksville, OH (US);

Assignee:

Oakwood Laboratories LLC, Oakwood Village, OH (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/00 (2006.01); A61K 9/10 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5031 (2013.01); A61K 9/0019 (2013.01); A61K 9/10 (2013.01); A61K 9/5089 (2013.01); A61K 31/485 (2013.01);
Abstract

A sustained release microsphere formulation with a high drug load may be formed by a continuous oil-in-water emulsion process by combining an organic dispersed phase with an aqueous continuous phase. The dispersed phase may include an encapsulating polymer, a primary solvent, such as dichloromethane, a pharmaceutically effective amount of an active agent having a solubility relative to the dispersed phase, and a co-solvent, such as benzyl alcohol, which is capable of increasing the solubility of the active agent relative to the dispersed phase. The continuous phase may include an aqueous solution of polyvinyl alcohol and water.


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