The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2017

Filed:

Oct. 08, 2011
Applicants:

Xiaofeng Zeng, Shanghai, CN;

Yue Zhang, Shanghai, CN;

Zhinan Shou, Shanghai, CN;

Hua Mao, Shanghai, CN;

Hongbin Sun, Shanghai, CN;

Jie Qian, Shanghai, CN;

Yongjun Han, Shanghai, CN;

Weina Situ, Shanghai, CN;

Inventors:

Xiaofeng Zeng, Shanghai, CN;

Yue Zhang, Shanghai, CN;

Zhinan Shou, Shanghai, CN;

Hua Mao, Shanghai, CN;

Hongbin Sun, Shanghai, CN;

Jie Qian, Shanghai, CN;

Yongjun Han, Shanghai, CN;

Weina Situ, Shanghai, CN;

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); C07K 14/705 (2006.01); C07K 14/52 (2006.01); C07K 16/18 (2006.01); G01N 33/564 (2006.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C07K 14/52 (2013.01); C07K 14/705 (2013.01); C07K 16/18 (2013.01); G01N 33/564 (2013.01); G01N 33/6854 (2013.01); A61K 38/19 (2013.01); G01N 2800/52 (2013.01);
Abstract

The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.


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