The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Nov. 16, 2015
University of Delaware, Newark, DE (US);
Christopher J. Roberts, West Grove, PA (US);
Gregory V. Barnett, Plainsboro, NJ (US);
Vladimir I. Razinkov, Thousand Oaks, CA (US);
Bruce A. Kerwin, Bainbridge Island, WA (US);
UNIVERSITY OF DELAWARE, Newark, DE (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
A method of determining the activation energy Efor degradation of a chemical species includes in sequence the steps of a) simultaneously incubating a plurality of samples of the chemical species in a single unitary device at a plurality of constant temperatures T, in each case for an incubation time t selected to result in loss of at most 20 mol % of the amount originally present; b) quenching each of the samples to stop degradation; c) determining the mole fraction m of the chemical species remaining in each of the quenched samples, relative to the amount present before incubating; d) determining for each sample a reaction rate coefficient kaccording to the equation and e) performing numerical regression of the kvalues obtained in step d) and the corresponding temperatures T in ° K to derive the activation energy Eaccording to the following equation or to derive a temperature-dependent activation energy if that is more appropriate for the chemical species of interest.