The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Jul. 09, 2015
Applicant:
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Inventors:
Masaaki Komatsu, Tokyo, JP;
Yoshinobu Ichimura, Tokyo, JP;
Assignee:
Tokyo Metropolitan Institute of Medical Science, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); C07K 16/18 (2006.01); C07K 16/44 (2006.01); C07K 14/47 (2006.01); C12Q 1/48 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57438 (2013.01); C07K 14/47 (2013.01); C07K 16/18 (2013.01); C07K 16/44 (2013.01); C12Q 1/485 (2013.01); G01N 33/57496 (2013.01); G01N 33/68 (2013.01); C07K 2317/34 (2013.01); G01N 2333/4703 (2013.01); G01N 2440/14 (2013.01); G01N 2500/02 (2013.01);
Abstract
The present invention provides antibodies useful for diagnosing and treating tumors as well as methods of screening for antitumor agents. More specifically, tumors can be diagnosed and treated using an anti-phosphorylated p62 antibody that recognizes phosphorylation of serine at position 351 of an amino acid sequence of SEQ ID No. 1 or at a position corresponding thereto. An antitumor agent can be obtained by screening for a substance that inhibits the phosphorylation or that dephosphorylates the phosphorylated serine.