The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Apr. 27, 2012
Ruchika Srivastava, Bangalore, IN;
Sneha Lakshmandas Hemdev, Bangalore, IN;
Ankur Bhatnagar, Bangalore, IN;
Saravanan Desan, Bangalore, IN;
Anuj Goel, Bangalore, IN;
Harish Iyer, Bangalore, IN;
Ruchika Srivastava, Bangalore, IN;
Sneha Lakshmandas Hemdev, Bangalore, IN;
Ankur Bhatnagar, Bangalore, IN;
Saravanan Desan, Bangalore, IN;
Anuj Goel, Bangalore, IN;
Harish Iyer, Bangalore, IN;
Biocon Research Limited, Karnataka, IN;
Abstract
The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile