The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2017

Filed:

Nov. 19, 2012
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Washington, DC (US);

Inventors:

Bruce A. Shapiro, Gaithersburg, MD (US);

Kirill A. Afonin, Frederick, MD (US);

Mathias D. Viard, Frederick, MD (US);

Eckart H. Bindewald, Frederick, MD (US);

Luc Jaeger, Goleta, CA (US);

Arti N. Santhanam, Elliott City, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 15/1132 (2013.01); C12N 15/1135 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/51 (2013.01);
Abstract

Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.


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