The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Aug. 11, 2011
Jinming Gao, Plano, TX (US);
David Boothman, Dallas, TX (US);
Yinjian Zhou, Beijing, CN;
Erik Bey, Morgantown, WV (US);
Jinming Gao, Plano, TX (US);
David Boothman, Dallas, TX (US);
Yinjian Zhou, Beijing, CN;
Erik Bey, Morgantown, WV (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
Disclosed herein are compounds comprising a polymer conjugated with a pH-sensitive prodrug of beta-lapachone, wherein the compound is capable of forming a micelle, and wherein the pH-sensitive prodrug comprises a pH-sensitive linker selected from the group consisting of: an aryl imine and an aliphatic imine. Also provided are micelles comprised of such polymer-prodrug conjugates. Further provided are methods for treating cancer with the micelles.