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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9631014 B1

PDFFull Text
Expired
Date of Patent:
Apr. 25, 2017

Filed:

Apr. 03, 2014

Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease

Applicant:

Sapporo Medical University, Hokkaido, JP;

Inventors:

Tsukasa Hori, Hokkaido, JP;

Yasuo Kokai, Hokkaido, JP;

Yasuyoshi Naishiro, Hokkaido, JP;

Hiroyuki Tsutsumi, Hokkaido, JP;

Kohzoh Imai, Hokkaido, JP;

Assignee:

SAPPORO MEDICAL UNIVERSITY, Hokkaido, JP;

Attorney:

Pearne & Gordon LLP

Primary Examiner:

Zachary Skelding

Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/24 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01); G01N 30/88 (2006.01);
U.S. Cl.
CPC ...
C07K 16/24 (2013.01); G01N 33/6863 (2013.01); A61K 2039/505 (2013.01); G01N 2030/8831 (2013.01); G01N 2333/523 (2013.01); G01N 2800/245 (2013.01);
Abstract

Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody.

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Hori, Tsukasa. (2017). Method and reagent for diagnosis and/or evaluation of progression of graft-versus-host disease (U.S. Patent No. 9631014). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9631014

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