The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Aug. 17, 2015
Applicant:
Ucb Pharma Gmbh, Monheim, DE;
Inventors:
Alain Merschaert, Brussels, BE;
Christophe Joseph Szczepaniak, Brussels, BE;
Joerg Hamann, Köln, DE;
Ralf Kanzler, Leverkusen, DE;
Assignee:
UCB Pharma GmbH, Monheim, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07C 231/14 (2006.01); C07C 227/34 (2006.01); C07C 227/18 (2006.01); C07C 237/22 (2006.01); C12P 13/06 (2006.01); C12P 13/04 (2006.01); C07C 231/02 (2006.01); C12P 41/00 (2006.01);
U.S. Cl.
CPC ...
C07C 231/02 (2013.01); C07C 227/18 (2013.01); C07C 227/34 (2013.01); C07C 231/14 (2013.01); C07C 237/22 (2013.01); C12P 13/04 (2013.01); C12P 13/06 (2013.01); C12P 41/007 (2013.01); C07B 2200/07 (2013.01);
Abstract
The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.