The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2017
Filed:
Sep. 02, 2011
Ralph A. Reisfeld, LaJolla, CA (US);
Rong Xiang, San Diego, CA (US);
Yunping Luo, San Diego, CA (US);
Debbie Liao, San Diego, CA (US);
Ze Liu, Beijing, CN;
Tingmei Chen, Chongqing, CN;
SI Chen, Tianjin, CN;
Dan LU, San Diego, CA (US);
Ralph A. Reisfeld, LaJolla, CA (US);
Rong Xiang, San Diego, CA (US);
Yunping Luo, San Diego, CA (US);
Debbie Liao, San Diego, CA (US);
Ze Liu, Beijing, CN;
Tingmei Chen, Chongqing, CN;
Si Chen, Tianjin, CN;
Dan Lu, San Diego, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.