The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 25, 2017

Filed:

Aug. 12, 2011
Applicants:

Michael Tymianski, Toronto, CA;

Peter S. LU, Fremont, CA (US);

Jonathan David Garman, Thornhill, CA;

Inventors:

Michael Tymianski, Toronto, CA;

Peter S. Lu, Fremont, CA (US);

Jonathan David Garman, Thornhill, CA;

Assignee:

NoNO Inc., Toronto, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/07 (2006.01); A61K 38/08 (2006.01); C07K 7/06 (2006.01); A61K 47/48 (2006.01); G01N 33/573 (2006.01); G01N 33/68 (2006.01); C12N 9/02 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
A61K 38/07 (2013.01); A61K 38/08 (2013.01); A61K 38/1709 (2013.01); A61K 38/1787 (2013.01); A61K 47/48315 (2013.01); C07K 7/06 (2013.01); C12N 9/0075 (2013.01); C12Y 114/13039 (2013.01); G01N 33/573 (2013.01); G01N 33/6872 (2013.01); C07K 2319/10 (2013.01); G01N 2333/70571 (2013.01); G01N 2333/90254 (2013.01); G01N 2500/02 (2013.01);
Abstract

The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).


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