The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 18, 2017

Filed:

Sep. 23, 2011
Applicants:

Xiao Xu, San Diego, CA (US);

Yama Abassi, San Diego, CA (US);

Xiaobo Wang, San Diego, CA (US);

Jiangbo Gan, San Diego, CA (US);

Inventors:

Xiao Xu, San Diego, CA (US);

Yama Abassi, San Diego, CA (US);

Xiaobo Wang, San Diego, CA (US);

Jiangbo Gan, San Diego, CA (US);

Assignee:

ACEA Biosciences, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 (2006.01); G01N 33/68 (2006.01); C12M 1/12 (2006.01); G01N 33/50 (2006.01); G01N 33/483 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6854 (2013.01); C12M 25/08 (2013.01); C12M 41/36 (2013.01); G01N 33/4836 (2013.01); G01N 33/5005 (2013.01); G01N 2500/10 (2013.01);
Abstract

The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In another aspect, the invention provides cellular assays that use impedance monitoring to detect changes in cell behavior or state. In some preferred aspects, the assays are designed to investigate the affects of compounds on cells, such as cytotoxicity assays.


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