The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2017
Filed:
May. 15, 2014
Bernhard Geierstanger, San Diego, CA (US);
Weijia Ou, San Diego, CA (US);
Susan E. Cellitti, San Diego, CA (US);
Tetsuo Uno, San Diego, CA (US);
Tiffany Crossgrove, York, ME (US);
Hsien-po Chiu, San Diego, CA (US);
Jan Grunewald, San Diego, CA (US);
Xueshi Hao, San Diego, CA (US);
Bernhard Geierstanger, San Diego, CA (US);
Weijia Ou, San Diego, CA (US);
Susan E. Cellitti, San Diego, CA (US);
Tetsuo Uno, San Diego, CA (US);
Tiffany Crossgrove, York, ME (US);
Hsien-Po Chiu, San Diego, CA (US);
Jan Grunewald, San Diego, CA (US);
Xueshi Hao, San Diego, CA (US);
Novartis AG, Basel, CH;
Abstract
Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analog, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.