The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 18, 2017

Filed:

Mar. 09, 2012
Applicants:

Matthias Nahrendorf, Charlestown, MA (US);

Ralph Weissleder, Peabody, MA (US);

Gerhard Dickneite, Marburg, DE;

Guido Stoll, Rimpar, DE;

Marc Nolte, Lahntal, DE;

Inventors:

Matthias Nahrendorf, Charlestown, MA (US);

Ralph Weissleder, Peabody, MA (US);

Gerhard Dickneite, Marburg, DE;

Guido Stoll, Rimpar, DE;

Marc Nolte, Lahntal, DE;

Assignees:

The General Hospital Corporation, Boston, MA (US);

CSL Behring GmbH, Marburg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/48 (2006.01); C07K 14/81 (2006.01); C07K 16/40 (2006.01); A61K 38/55 (2006.01); A61K 38/57 (2006.01); A61K 49/00 (2006.01); A61K 49/14 (2006.01); G01N 33/50 (2006.01); A61K 39/395 (2006.01); C07K 16/36 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 38/556 (2013.01); A61K 38/57 (2013.01); A61K 39/3955 (2013.01); A61K 49/0004 (2013.01); A61K 49/0008 (2013.01); A61K 49/14 (2013.01); C07K 14/811 (2013.01); C07K 16/36 (2013.01); G01N 33/5088 (2013.01); A61K 38/4846 (2013.01); C07K 14/8114 (2013.01); G01N 2500/10 (2013.01);
Abstract

Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.


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