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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9624225 B1

PDFFull Text
Date of Patent:
Apr. 18, 2017

Filed:

Oct. 14, 2014

Quinolinyl modulators of rorγt

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Kristi A. Leonard, Lansdale, PA (US);

Kent Barbay, Sunnybrook, PA (US);

James P. Edwards, San Diego, CA (US);

Kevin D. Kreutter, Plainsboro, NJ (US);

David A. Kummer, San Diego, CA (US);

Umar Maharoof, North Wales, PA (US);

Rachel Nishimura, San Diego, CA (US);

Maud Urbanski, Flemington, NJ (US);

Hariharan Venkatesan, San Diego, CA (US);

Aihua Wang, Jamison, PA (US);

Ronald L. Wolin, San Diego, CA (US);

Craig R. Woods, San Diego, CA (US);

Xiaohua Xue, San Diego, CA (US);

Maxwell D. Cummings, Ambler, PA (US);

Kelly McClure, Ramona, CA (US);

Virginia Tanis, Vista, CA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Yuriy P. Stercho

Primary Examiner:

Nizal Chandrakumar

Int. Cl.
CPC ...
A01N 43/00 (2006.01); C07D 487/04 (2006.01); A61K 31/5377 (2006.01); A61K 31/4985 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/4709 (2006.01); C07D 401/14 (2006.01); A61K 45/06 (2006.01); C07D 405/14 (2006.01); C07D 401/06 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 409/14 (2006.01); A61K 31/5365 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5365 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

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