The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2017
Filed:
Jul. 18, 2014
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Shuxing Zhang, Pearland, TX (US);
Hui-Kuan Lin, Winston-Salem, NC (US);
Chia-Hsin Chan, Houston, TX (US);
John Kenneth Morrow, San Diego, CA (US);
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); A61K 31/454 (2006.01); A61K 31/428 (2006.01); A61K 31/5377 (2006.01); A61K 31/352 (2006.01); C07D 405/04 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); A61K 31/4184 (2006.01); A61K 31/423 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/352 (2013.01); A61K 31/4184 (2013.01); A61K 31/423 (2013.01); A61K 31/428 (2013.01); A61K 31/454 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 405/04 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01);
Abstract
Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.