The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 18, 2017

Filed:

Oct. 23, 2013
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Joseph E. Pero, Harleysville, PA (US);

Hannah D. G. F. Lehman, Boyertown, PA (US);

Michael J. Kelly, III, Paoli, PA (US);

Lianyun Zhao, Ambler, PA (US);

Michael A. Rossi, Middleton, DE (US);

Dansu Li, Warrington, PA (US);

Kevin F. Gilbert, Barto, PA (US);

Scott Wolkenberg, Wyndmoor, PA (US);

James Mulhearn, Elkins Park, PA (US);

Mark E. Layton, Harleysville, PA (US);

Pablo de Leon, Baltimore, MD (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 263/58 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
C07D 413/14 (2013.01); A61K 31/44 (2013.01); C07D 263/58 (2013.01); C07D 413/12 (2013.01);
Abstract

Disclosed are compounds of Formula A: Formula A, or a salt thereof, wherein 'Het', R, and Rare defined herein, which have properties for blocking Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating neuropathic pain disorders using the same.


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