IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9624200 B1

PDFFull Text
Date of Patent:
Apr. 18, 2017

Filed:

Oct. 07, 2014

Therapeutic piperazines

Applicant:

Dart Neuroscience (Cayman) Ltd., Grand Cayman, KY;

Inventors:

Alan P. Kaplan, San Diego, CA (US);

Terence P. Keenan, San Diego, CA (US);

Michael I. Weinhouse, Escondido, CA (US);

Mark E. Wilson, Ramona, CA (US);

Andrew K. Lindstrom, San Diego, CA (US);

William C. Ripka, San Diego, CA (US);

Mi Chen, San Diego, CA (US);

Assignee:

Dart NeuroScience (Cayman) Ltd., , KY;

Attorney:

Knobbe Martens Olson & Bear LLP

Primary Examiner:

Alexander R Pagano

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
A61K 31/551 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); C07D 403/04 (2006.01); C07D 401/04 (2006.01); C07D 417/14 (2006.01); C07D 409/06 (2006.01); C07D 243/08 (2006.01); C07D 241/04 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 403/06 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 401/06 (2006.01); C07D 413/06 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/06 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 241/04 (2013.01); C07D 243/08 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 417/06 (2013.01); C07D 417/14 (2013.01);
Abstract

The invention includes a compound of formula I: wherein R, Y, A, n, Rand Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function and/or treating cognitive disorders or impairment, traumatic and/or ischemic injuries of the central and peripheral nervous system and/or psychiatric disorders in animals, especially humans.

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