The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2017
Filed:
Nov. 08, 2012
Applicant:
Celverum Inc., Ottawa, CA;
Inventors:
Assignee:
Celverum Inc., Ottawa, CA;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C12N 5/09 (2010.01);
U.S. Cl.
CPC ...
A61K 39/0011 (2013.01); C12N 5/0693 (2013.01); C12N 5/0694 (2013.01); A61K 2039/5152 (2013.01); A61K 2039/5156 (2013.01); C12N 2510/00 (2013.01); C12N 2760/20032 (2013.01); C12N 2770/36032 (2013.01);
Abstract
An immunogenic formulation for a patient, the formulation includes virus-modulated hematopoietic cancer cells, where the modulated hematopoietic cancer cells are generated from viable hematopoietic cancer cells obtained from the patient, either isolated or in a mixed hematopoietic population of healthy and cancer cells, and where the viable hematopoietic cancer cells are infected ex vivo with a virus that modulates the expression of a plurality of endogenous immune regulatory molecules to increase the immunogenicity of the hematopoietic cancer cells.