The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2017
Filed:
Mar. 30, 2012
Applicants:
Teruo Okano, Tokyo, JP;
Tatsuya Shimizu, Tokyo, JP;
Jun Yamashita, Kyoto, JP;
Hidetoshi Masumoto, Kyoto, JP;
Inventors:
Teruo Okano, Tokyo, JP;
Tatsuya Shimizu, Tokyo, JP;
Jun Yamashita, Kyoto, JP;
Hidetoshi Masumoto, Kyoto, JP;
Assignees:
Tokyo Women's Medical University, Tokyo, JP;
Kyoto University, Kyoto, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/34 (2015.01); C12N 5/077 (2010.01); C12N 5/071 (2010.01); A61K 35/44 (2015.01); A61K 9/70 (2006.01);
U.S. Cl.
CPC ...
A61K 35/34 (2013.01); A61K 9/70 (2013.01); A61K 35/44 (2013.01); C12N 5/0657 (2013.01); C12N 5/0697 (2013.01); C12N 2501/01 (2013.01); C12N 2501/04 (2013.01); C12N 2501/165 (2013.01); C12N 2502/1329 (2013.01); C12N 2502/1347 (2013.01); C12N 2502/28 (2013.01); C12N 2506/02 (2013.01);
Abstract
The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.