Date of Patent: Apr. 18, 2017 Applicant:
Ligand Pharmaceuticals Inc. , La Jolla, CA (US) ;
Inventors:
Lin Zhi , San Diego, CA (US) ;
Andrew R. Hudson , San Diego, CA (US) ;
Cornelis A. Van Oeveren , San Diego, CA (US) ;
Steven L. Roach , San Diego, CA (US) ;
Bijan Pedram , San Diego, CA (US) ;
Yixing Shen , Encinitas, CA (US) ;
Lino J. Valdez , San Diego, CA (US) ;
Jillian Basinger , San Diego, CA (US) ;
Virginia Heather Sharron Grant , San Diego, CA (US) ;
Jason C. Pickens , Chula Vista, CA (US) ;
Int. Cl.
CPC ...
A61K 31/15 (2006.01) ; A61K 31/167 (2006.01) ; A61K 31/18 (2006.01) ; A61K 31/245 (2006.01) ; A61K 31/343 (2006.01) ; A61K 31/36 (2006.01) ; A61K 31/381 (2006.01) ; A61K 31/4015 (2006.01) ; A61K 31/402 (2006.01) ; A61K 31/4025 (2006.01) ; A61K 31/404 (2006.01) ; A61K 31/4045 (2006.01) ; A61K 31/41 (2006.01) ; A61K 31/415 (2006.01) ; A61K 31/4155 (2006.01) ; A61K 31/405 (2006.01) ; A61K 31/416 (2006.01) ; A61K 31/4164 (2006.01) ; A61K 31/4184 (2006.01) ; A61K 31/4192 (2006.01) ; A61K 31/421 (2006.01) ; A61K 31/423 (2006.01) ; A61K 31/4245 (2006.01) ; A61K 31/437 (2006.01) ; A61K 31/438 (2006.01) ; A61K 31/4409 (2006.01) ; A61K 31/4418 (2006.01) ; A61K 31/4439 (2006.01) ; A61K 31/4468 (2006.01) ; A61K 31/4535 (2006.01) ; A61K 31/454 (2006.01) ; A61K 31/4747 (2006.01) ; A61K 31/495 (2006.01) ; A61K 31/4985 (2006.01) ; A61K 31/501 (2006.01) ; A61K 31/506 (2006.01) ; A61K 31/5375 (2006.01) ; A61K 31/5377 (2006.01) ; A61K 31/538 (2006.01) ; A61K 31/541 (2006.01) ; C07C 233/78 (2006.01) ; C07C 233/80 (2006.01) ; C07C 235/56 (2006.01) ; C07C 237/40 (2006.01) ; C07C 237/42 (2006.01) ; C07C 243/38 (2006.01) ; C07C 247/18 (2006.01) ; C07C 251/48 (2006.01) ; C07C 251/66 (2006.01) ; C07C 251/68 (2006.01) ; C07C 251/86 (2006.01) ; C07C 271/28 (2006.01) ; C07C 311/08 (2006.01) ; C07D 207/12 (2006.01) ; C07D 207/27 (2006.01) ; C07D 207/273 (2006.01) ; C07D 207/32 (2006.01) ; C07D 207/327 (2006.01) ; C07D 207/34 (2006.01) ; C07D 207/416 (2006.01) ; C07D 209/08 (2006.01) ; C07D 209/12 (2006.01) ; C07D 209/14 (2006.01) ; C07D 209/16 (2006.01) ; C07D 209/24 (2006.01) ; C07D 209/34 (2006.01) ; C07D 209/42 (2006.01) ; C07D 211/46 (2006.01) ; C07D 211/58 (2006.01) ; C07D 213/12 (2006.01) ; C07D 213/53 (2006.01) ; C07D 213/79 (2006.01) ; C07D 213/80 (2006.01) ; C07D 213/81 (2006.01) ; C07D 213/82 (2006.01) ; C07D 231/14 (2006.01) ; C07D 231/26 (2006.01) ; C07D 231/40 (2006.01) ; C07D 231/56 (2006.01) ; C07D 233/60 (2006.01) ; C07D 233/61 (2006.01) ; C07D 233/90 (2006.01) ; C07D 235/06 (2006.01) ; C07D 235/14 (2006.01) ; C07D 235/20 (2006.01) ; C07D 235/24 (2006.01) ; C07D 235/30 (2006.01) ; C07D 237/24 (2006.01) ; C07D 239/28 (2006.01) ; C07D 241/04 (2006.01) ; C07D 241/24 (2006.01) ; C07D 249/04 (2006.01) ; C07D 261/18 (2006.01) ; C07D 263/04 (2006.01) ; C07D 263/16 (2006.01) ; C07D 263/57 (2006.01) ; C07D 265/36 (2006.01) ; C07D 277/56 (2006.01) ; C07D 285/06 (2006.01) ; C07D 295/135 (2006.01) ; C07D 295/155 (2006.01) ; C07D 295/185 (2006.01) ; C07D 307/68 (2006.01) ; C07D 317/62 (2006.01) ; C07D 317/68 (2006.01) ; C07D 333/24 (2006.01) ; C07D 333/38 (2006.01) ; C07D 401/04 (2006.01) ; C07D 401/10 (2006.01) ; C07D 401/12 (2006.01) ; C07D 401/14 (2006.01) ; C07D 403/10 (2006.01) ; C07D 403/12 (2006.01) ; C07D 405/04 (2006.01) ; C07D 405/10 (2006.01) ; C07D 409/04 (2006.01) ; C07D 409/12 (2006.01) ; C07D 413/10 (2006.01) ; C07D 413/12 (2006.01) ; C07D 413/14 (2006.01) ; C07D 417/10 (2006.01) ; C07D 417/12 (2006.01) ; C07D 471/04 (2006.01) ; C07D 491/113 (2006.01) ; C07D 409/14 (2006.01) ; C07D 417/14 (2006.01) ;
U.S. Cl.
CPC ...
A61K 31/15 (2013.01) ; A61K 31/167 (2013.01) ; A61K 31/18 (2013.01) ; A61K 31/245 (2013.01) ; A61K 31/343 (2013.01) ; A61K 31/36 (2013.01) ; A61K 31/381 (2013.01) ; A61K 31/402 (2013.01) ; A61K 31/404 (2013.01) ; A61K 31/405 (2013.01) ; A61K 31/4015 (2013.01) ; A61K 31/4025 (2013.01) ; A61K 31/4045 (2013.01) ; A61K 31/41 (2013.01) ; A61K 31/415 (2013.01) ; A61K 31/416 (2013.01) ; A61K 31/4155 (2013.01) ; A61K 31/4164 (2013.01) ; A61K 31/4184 (2013.01) ; A61K 31/4192 (2013.01) ; A61K 31/421 (2013.01) ; A61K 31/423 (2013.01) ; A61K 31/4245 (2013.01) ; A61K 31/437 (2013.01) ; A61K 31/438 (2013.01) ; A61K 31/4409 (2013.01) ; A61K 31/4418 (2013.01) ; A61K 31/4439 (2013.01) ; A61K 31/4468 (2013.01) ; A61K 31/454 (2013.01) ; A61K 31/4535 (2013.01) ; A61K 31/4747 (2013.01) ; A61K 31/495 (2013.01) ; A61K 31/4985 (2013.01) ; A61K 31/501 (2013.01) ; A61K 31/506 (2013.01) ; A61K 31/538 (2013.01) ; A61K 31/5375 (2013.01) ; A61K 31/5377 (2013.01) ; A61K 31/541 (2013.01) ; C07C 233/78 (2013.01) ; C07C 233/80 (2013.01) ; C07C 235/56 (2013.01) ; C07C 237/40 (2013.01) ; C07C 237/42 (2013.01) ; C07C 243/38 (2013.01) ; C07C 247/18 (2013.01) ; C07C 251/48 (2013.01) ; C07C 251/66 (2013.01) ; C07C 251/68 (2013.01) ; C07C 251/86 (2013.01) ; C07C 271/28 (2013.01) ; C07C 311/08 (2013.01) ; C07D 207/12 (2013.01) ; C07D 207/27 (2013.01) ; C07D 207/273 (2013.01) ; C07D 207/32 (2013.01) ; C07D 207/327 (2013.01) ; C07D 207/34 (2013.01) ; C07D 207/416 (2013.01) ; C07D 209/08 (2013.01) ; C07D 209/12 (2013.01) ; C07D 209/14 (2013.01) ; C07D 209/16 (2013.01) ; C07D 209/24 (2013.01) ; C07D 209/34 (2013.01) ; C07D 209/42 (2013.01) ; C07D 211/46 (2013.01) ; C07D 211/58 (2013.01) ; C07D 213/12 (2013.01) ; C07D 213/53 (2013.01) ; C07D 213/79 (2013.01) ; C07D 213/80 (2013.01) ; C07D 213/81 (2013.01) ; C07D 213/82 (2013.01) ; C07D 231/14 (2013.01) ; C07D 231/26 (2013.01) ; C07D 231/40 (2013.01) ; C07D 231/56 (2013.01) ; C07D 233/60 (2013.01) ; C07D 233/61 (2013.01) ; C07D 233/90 (2013.01) ; C07D 235/06 (2013.01) ; C07D 235/14 (2013.01) ; C07D 235/20 (2013.01) ; C07D 235/24 (2013.01) ; C07D 235/30 (2013.01) ; C07D 237/24 (2013.01) ; C07D 239/28 (2013.01) ; C07D 241/04 (2013.01) ; C07D 241/24 (2013.01) ; C07D 249/04 (2013.01) ; C07D 261/18 (2013.01) ; C07D 263/04 (2013.01) ; C07D 263/16 (2013.01) ; C07D 263/57 (2013.01) ; C07D 265/36 (2013.01) ; C07D 277/56 (2013.01) ; C07D 285/06 (2013.01) ; C07D 295/135 (2013.01) ; C07D 295/155 (2013.01) ; C07D 295/185 (2013.01) ; C07D 307/68 (2013.01) ; C07D 317/62 (2013.01) ; C07D 317/68 (2013.01) ; C07D 333/24 (2013.01) ; C07D 333/38 (2013.01) ; C07D 401/04 (2013.01) ; C07D 401/10 (2013.01) ; C07D 401/12 (2013.01) ; C07D 401/14 (2013.01) ; C07D 403/10 (2013.01) ; C07D 403/12 (2013.01) ; C07D 405/04 (2013.01) ; C07D 405/10 (2013.01) ; C07D 409/04 (2013.01) ; C07D 409/12 (2013.01) ; C07D 409/14 (2013.01) ; C07D 413/10 (2013.01) ; C07D 413/12 (2013.01) ; C07D 413/14 (2013.01) ; C07D 417/10 (2013.01) ; C07D 417/12 (2013.01) ; C07D 417/14 (2013.01) ; C07D 471/04 (2013.01) ; C07D 491/113 (2013.01) ;
Abstract The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
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