The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Jul. 12, 2013
Shin Nippon Biomedical Laboratories, Ltd., Kagoshima-shi, JP;
Wave Life Sciences Japan, Kagoshima-shi, JP;
Takefumi Gemba, Kagoshima, JP;
Shin Nippon Biomedical Laboratories, Ltd., Kagoshima-shi, JP;
WAVE LIFE SCIENCES JAPAN, Kagoshima-shi, JP;
Abstract
Problem The purpose of the present invention is to provide: a stereo isomer of a novel CpG oligonucleotide, which has excellent stability; and a CpG oligonucleotide which has a capability of producing interferon-α (IFNα). Solution The present invention relates to an oligonucleotide which contains two to four sequences each represented by the formula 5'-XXCpGXX-3′ (formula (I)) and has a length of 14 to 32 nucleotides. In formula (I), CpG represents a non-methylated CpG residue having a phosphate skeleton modification, XXrepresents any one of AA, AT, GA and GT, and XXrepresents any one of TT, AT, AC and CG. The oligonucleotide has at least one phosphate skeleton modification at an S-form stereoisomer located at a site other than the CpG.