The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Oct. 21, 2014
Applicant:
Hemoshear, Llc, Charlottesville, VA (US);
Inventors:
Brian R. Wamhoff, Charlottesville, VA (US);
Brett R. Blackman, Charlottesville, VA (US);
Robert A. Figler, Earlysville, VA (US);
Daniel G. Gioeli, Charlottesville, VA (US);
Michael B. Simmers, Charlottesville, VA (US);
Assignee:
HemoShear, LLC, Charlottesville, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/09 (2010.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0693 (2013.01); C12N 5/067 (2013.01); C12N 5/0697 (2013.01); C12N 2502/1323 (2013.01); C12N 2502/28 (2013.01); C12N 2502/30 (2013.01); C12N 2503/04 (2013.01); C12N 2521/00 (2013.01); C12N 2533/54 (2013.01);
Abstract
Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.