logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9617517 B1

PDFFull Text
Date of Patent:
Apr. 11, 2017

Filed:

May. 01, 2012

Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound

Applicants:

Shoen Kume, Kumamoto, JP;

Daisuke Sakano, Kumamoto, JP;

Nobuaki Shiraki, Kumamoto, JP;

Kahoko Umeda, Kumamoto, JP;

Taiji Yamazoe, Kumamoto, JP;

Kazuhiko Kume, Kumamoto, JP;

Motonari Uesugi, Kyoto, JP;

Inventors:

Shoen Kume, Kumamoto, JP;

Daisuke Sakano, Kumamoto, JP;

Nobuaki Shiraki, Kumamoto, JP;

Kahoko Umeda, Kumamoto, JP;

Taiji Yamazoe, Kumamoto, JP;

Kazuhiko Kume, Kumamoto, JP;

Motonari Uesugi, Kyoto, JP;

Assignees:

NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, Kumamoto, JP;

KYOTO UNIVERSITY, Kyoto, JP;

Attorneys:

Michael Ye

Andrews Kurth Kenyon LLP

Primary Examiner:

Lynn Fan

Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 45/06 (2006.01); A61K 31/198 (2006.01); A61K 31/221 (2006.01); A61K 31/405 (2006.01); A61K 31/407 (2006.01); A61K 31/4375 (2006.01); A61K 31/4745 (2006.01); A61K 31/48 (2006.01); A61K 31/525 (2006.01); A61K 31/475 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); A61K 31/198 (2013.01); A61K 31/221 (2013.01); A61K 31/405 (2013.01); A61K 31/407 (2013.01); A61K 31/4375 (2013.01); A61K 31/475 (2013.01); A61K 31/4745 (2013.01); A61K 31/48 (2013.01); A61K 31/525 (2013.01); A61K 45/06 (2013.01); C12N 5/0678 (2013.01); C12N 2501/115 (2013.01); C12N 2501/385 (2013.01); C12N 2506/02 (2013.01); C12N 2510/00 (2013.01);
Abstract

A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of ES cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of ES cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells. Another purpose of the present invention is to provide the thus-induced insulin-producing cells. Provided are: an agent for promoting induction of the differentiation of stem cells derived from a mammal into insulin-producing cells, which contains a compound that is selected from the group consisting of dopamine metabolism inhibitors, serotonin metabolism inhibitors, acetylchotine, acetylcholine degrading enzyme inhibitors and acetylcholine receptor activators; and a method for inducing differentiation using the agent for promoting induction of differentiation.

Find Patent Forward Citations

Loading…