The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Feb. 08, 2016
Applicant:
Technion Research & Development Foundation Limited, Haifa, IL;
Inventor:
Gera Neufeld, Haifa, IL;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 39/395 (2006.01); C07K 16/40 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); C12N 15/1137 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); C12Y 104/03013 (2013.01); G01N 33/573 (2013.01); C07K 2317/76 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/90638 (2013.01);
Abstract
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.