The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Mar. 14, 2014
Biogen MA Inc., Cambridge, MA (US);
Tracy Jenkins, Cambridge, MA (US);
Jeffery Vessels, Cambridge, MA (US);
BIOGEN MA INC., Cambridge, MA (US);
Abstract
Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; Ris absent, heteroarylene, arylene, C1-3 alkylene, or Rand Rtaken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; Ris absent, C(O)NR, NRor O; Ris C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an O, S, SO, SOor NR, and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; Ris absent, NRor O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases.