The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2017
Filed:
Aug. 07, 2015
Pfizer Inc., New York, NY (US);
Jotham Wadsworth Coe, Niantic, CT (US);
John Arthur Allen, Billerica, MA (US);
Jennifer Elizabeth Davoren, Cambridge, MA (US);
Amy Beth Dounay, Colorado Springs, CO (US);
Ivan Viktorovich Efremov, Brookline, MA (US);
David Lawrence Firman Gray, Groton, MA (US);
Edward Raymond Guilmette, Franklin, MA (US);
Anthony Richard Harris, Narragansett, RI (US);
Chris John Helal, Mystic, CT (US);
Jaclyn Louise Henderson, Cambridge, MA (US);
Scot Richard Mente, Arlington, MA (US);
Deane Milford Nason, Norwich, CT (US);
Steven Victor O'Neil, East Lyme, CT (US);
Chakrapani Subramanyam, South Glastonbury, CT (US);
Wenjian Xu, Waterford, CT (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.